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Revolutionizing Drug Discovery: The Game-Changing Echo MS+ System by SCIEX

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Ayanna Amadi
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Revolutionizing Drug Discovery: The Game-Changing Echo MS+ System by SCIEX

Revolutionizing Drug Discovery: The Game-Changing Echo MS+ System by SCIEX

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Pharmaceutical research and development has taken a giant leap forward with the introduction of the Echo MS+ system by SCIEX. This revolutionary piece of technology integrates acoustic ejection mass spectrometry (AEMS) with the SCIEX ZenoTOF 7600 system, enhancing high-throughput screening capabilities for drug discovery. The Echo MS+ system addresses the key challenges in high-throughput screening, providing precise qualitative and quantitative results through expanded screening workflows. The system significantly improves selectivity and sensitivity, reducing time, cost, and risk in drug development, and facilitating faster, more confident decision-making processes in hit identification and lead optimization. This ultimately speeds up the drug discovery process.

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The Echo MS+ System: A Closer Look

The Echo MS+ system offers a high sample throughput with sampling rates of up to 1 sample per second. It successfully addresses the challenges in qualitative and quantitative mass spectrometry analysis, delivering high-quality data, while minimizing sample handling. The system is compatible with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system and can be paired with robotic automation systems. It leverages Acoustic Ejection Mass Spectrometry (AEMS) and is ideal for drug discovery, providing powerful MS/MS sensitivity and data-independent acquisition. It is also listed as part of the SCIEX clinical diagnostic portfolio.

Unmatched Speed, Robustness, and Accuracy

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The Echo MS+ system delivers unmatched speed, robustness, and accuracy, meeting evolving lab requirements. It optimizes tandem mass spectrometry, quantifies and identifies low-abundance analytes, and offers streamlined drug screening solutions. The system comes with a range of accessories, software, and support plans and finds applications in various fields such as biologics, genomics, clinical diagnostics, drug discovery, environmental analysis, food safety, forensic analysis, and academic research. It provides easy access to personalized support, instrument management, software activation, and training resources through the SCIEX account.

Impact on High-Throughput Screening Applications

The Echo MS+ system is a breakthrough in high-throughput screening applications for drug discovery. It eliminates the need for extensive method development and delivers precise qualitative and quantitative results through a robust panel of high-throughput screening workflows. This allows researchers to make faster and more confident decisions in hit identification and lead optimization, reducing the time, cost, and risk in the early phases of drug development.

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Flexible Workflows and Future Developments

Launched at SLAS 2024, the Echo MS+ system offers new, flexible workflows for small and large molecules, leveraging high-resolution mass spectrometry for improved selectivity and sensitivity. This gives researchers in drug discovery the ability to make faster and more confident decisions in hit identification and iterative lead optimization. SCIEX has plans to develop further new and novel workflows for the Echo MS+ system in collaboration with customers at their global Echo MS Center of Excellence.

The Echo MS+ System: A Disruptive Technology

The Echo MS+ system couples proprietary Acoustic Ejection Mass Spectrometry technology and Open Port Interface (OPI) sampling with the capabilities of either the SCIEX ZenoTOF 7600 or Triple Quad 6500+ system to deliver precise qualitative and quantitative results. This disruptive technology has the potential to change the face of high-throughput screening applications for drug discovery. SCIEX intends to continue developing new and novel workflows for the Echo MS+ system in collaboration with customers at their global Echo MS Center of Excellence to address key unmet analytical needs.

Drug Discovery
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